Inward Rectifier Potassium Channels (Kir2.x) and Caveolin-3 Domain-Specific Interaction: Implications for Purkinje Cell-Dependent Ventricular Arrhythmias.
| Author | |
|---|---|
| Abstract |
:
In human cardiac ventricle, IK1 is mainly comprised Kir2.1, but Kir2.2 and Kir2.3 heterotetramers occur and modulate IK1. Long-QT syndrome-9-associated CAV3 mutations cause decreased Kir2.1 current density, but Kir2.x heterotetramers have not been studied. Here, we determine the effect of long-QT syndrome-9-CAV3 mutation F97C on Kir2.x homo- and heterotetramers and model-associated arrhythmia mechanisms. |
| Year of Publication |
:
2018
|
| Journal |
:
Circulation. Arrhythmia and electrophysiology
|
| Volume |
:
11
|
| Issue |
:
1
|
| Number of Pages |
:
e005800
|
| ISSN Number |
:
1941-3149
|
| DOI |
:
10.1161/CIRCEP.117.005800
|
| Short Title |
:
Circ Arrhythm Electrophysiol
|
| Download citation |
