Skip to main content

Generation of a human induced pluripotent stem cell line (CSC-42) from a patient with sporadic form of Parkinson's disease.

Author
Abstract
:

Skin fibroblasts were collected from a 44-year-old patient with sporadic case of Parkinson's disease (PD). The non-integrating Sendai virus vector encoding OCT3/4, SOX2, c-MYC and KLF4 was used to reprogram fibroblasts into induced pluripotent stem cells (iPSCs). Generated iPSCs had normal karyotypes, expressed common stem cell markers, and were capable of differentiating into all three germ layers. Generated line could be used for PD modeling to understand the mechanisms that influence the disorder.

Year of Publication
:
2018
Journal
:
Stem cell research
Volume
:
27
Number of Pages
:
78-81
Date Published
:
2018
ISSN Number
:
1873-5061
URL
:
http://linkinghub.elsevier.com/retrieve/pii/S1873-5061(18)30002-3
DOI
:
10.1016/j.scr.2018.01.002
Short Title
:
Stem Cell Res
Download citation